الفهرس | Only 14 pages are availabe for public view |
Abstract y Organophosphorus compounds especially, α-aminophosphonic acids (I) and their esters (II), have a potential biological activity due to the similarity with α- amino acids (III). They represent an essential analogy to α-amino acids (III) as we replaced a carboxylic group with a phosphonic acid ester moiety (cf. scheme. 1). The development of efficient synthetic procedures to prepare new analogs are urgently needed in the field of organophosphorus chemistry. Scheme 1.Structures of α-aminophosphonic acids I, α-aminophosphonic esters II, and α -amino acids III In continuation of our previous work to improve synthesis and enhance the scalability of organophosphorus compounds to be used in different biological applications as antibacterial agents. In recent years metal-organic frameworks (MOFs) received much attention from many researchers and have been employed in numerous applications such as heterogeneous catalysts. This encourage us to study the catalytic application of MOF in one-pot three components KabachnikFields reaction in synthesis of α-aminophosphonates . |