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العنوان
Effect of Metoclopramide in Shortening the Length of Labour :
المؤلف
Khalaf, Ahmed Hamdy Saied.
هيئة الاعداد
باحث / أحمد حمدى سعيد خلف
مشرف / حامد السيد اللقوة
مناقش / ايمن عبد القادر شبانه
مناقش / هشام محمد السعيد
الموضوع
Obstetrics.
تاريخ النشر
2022.
عدد الصفحات
64 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
2/4/2022
مكان الإجازة
جامعة المنوفية - كلية الطب - امراض النساء والتوليد
الفهرس
Only 14 pages are availabe for public view

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from 74

Abstract

Labor is a natural physiological process characterized by a progressive increase in frequency, intensity, and duration of uterine contractions, effacement, and dilatation of the cervix with the descent of the fetus through the birth canal. Human labor divides into three stages. The first stage is further divided into two phases. Successful labor involves three factors, which include maternal efforts and uterine contractions, fetal characteristics, and pelvic anatomy. Prolonged labor can lead to increased maternal and neonatal mortality and morbidity due to increased risks of maternal exhaustion, postpartum hemorrhage and sepsis, fetal distress, and asphyxia and requires early detection and appropriate clinical response. Labor often begins spontaneously or may be induced medically for a variety of maternal or fetal indications. Methods of inducing labor include cervical ripening with prostaglandins, membrane stripping, amniotomy, and intravenous oxytocin.
Metoclopramide is an antiemetic drug that is widely used in obstetrics. Metoclopramide may have some effect on the smooth muscles of the cervix, inhibiting spasms that impair effective cervical dilatation and thus aiding in cervical relaxation.
This study aims to establish whether metoclopramide plays a role in shorting the length of labor as regards cervical dilatation
The current study is a randomized controlled trial (RCT) conducted at Etay Elbaroud Hospital during the period from March 2020 to March 2021. The study included 100 pregnant women who were admitted in labor. They were divided into two equal groups; each included 50 pregnant women. Each participant received a prefilled syringe with two millilitres of colourless solution (either metoclopramide or placebo) randomly assigned by a computer list.
Regarding demographic data present study showed no statistical differences between the two studied groups as regards age, gestational age, and parity. In addition, there were no statistical differences between the two studied groups regarding any of the assessed clinical parameters including (Pulse, BP Systolic, BP Diastolic, and Temperature)
On vaginal examination of the two groups, regarding the position of the fetal head most of the cases were LOA, the Station of the fetal head in the metoclopramide group was (-2, -1, and 0) in 26%, 40%, and 34% of cases respectively while in the placebo group it was (-2,-1 and 0)in 26%, 34% and 40% of cases respectively thus, there was a statistically significant difference between the two studied groups as regards the position of the fetal head (P-value = 0.035). But there was no statistically significant difference between the studied groups as regards the station of the fetal head (P> 0.05).
Regarding cervical dilatation, there were statistically significant differences between the two studied groups as regards cervical dilation at 2 hours, 4 hours, 6 hours, 8 hours, and 10 hours as p-values were 0.018*, 0.001*, >0.001**, >0.001**, and 0.043*, respectively.
SUMMARY