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Abstract Nonmelanoma skin cancer (NMSC) is the most common type of cancer. There are two primary types of non -melanoma skin cancer: squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), and they are both derived from the stratum basale of the epidermis. NMSC is commonly found in populations with fair skin. In the United States, NMSC incidence has increased with more than five million new cases each year. Further, those with a history of skin cancer are at an increased risk of developing other lethal types of cancer. Basal cell carcinoma accounts for 80–85% of skin cancer and is caused by intermittent UV exposure, particularly duringyouth. BCC rarely invades other tissues and grows slowly. Squamous cell carcinoma results from cumulative sun exposure and makes up around 15 to 20% of all skin cancers .SCC is common among those who work outdoors and are exposed to substantial UV radiation. SCC most frequently occurs on areas of the body which are most exposed to sunlight such as the face and head, and these cancers are capable of metastasizing. Oxidative stress plays an important role in the promotion and prevention of carcinogenesis. Relatively high levels of reactive molecules are required to activate proliferative and pro-survival signal transduction pathways while excessive oxidative stress causes sufficient damage to cellular DNA, proteins and lipids to activate cell death pathways .Thus, a therapeutic strategy that has been employed to elicit tumor cell death is to utilize agents that induce excessive oxidative stress. Several clinically available anticancer agents, including doxorubicin and bleomycin, induce tumor cell death by initiating lethal oxidative stress. |