الفهرس 
Respiratory failure in COPDOnly 14 pages are availabe for public view
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Abstract
Background: Mechanical ventilation is a daily event in any ICU, using NIV as a weaning facilitating strategy for mechanically ventilated patients after passing Spontaneous Breathing Trial (SBT) recently considered to reduce complications associated with invasive ventilation. Also NIV used early to avoid invasive ventilation especially with COPD patients. Aim of the Work: to compare the efficacy of noninvasive ventilation (NIV) to conventional strategy with face mask (FM) in preventing reintubation, if NIV is used immediately after elective extubation, in patients with respiratory failure due to chronic obstructive lung disease (COPD) requiring mechanical ventilation for more than 72 hours. Patients and Methods: A prospective randomized controlled study was carried out from June 2018 till May 2019, including 50 patients admitted to the intensive care unit at Ain Shams University hospitals. Approval of the ethical committee of Ain Shams University was obtained before the start of patient’s recruitment. Results: The overall reintubation rate was 20%. Ten of the 50 evaluated patients were reintubated within 48 hours after extubation. The reintubation rate was different in each group. ICU length of stay was statistically different between the groups, with a mean of 8.6 ± 2.1 days in the NIV group and 10.8 ± 3.9 days in the FM group (P = 0.024). Hospital mortality rate (within about 30 days) showed a statistically significant difference between groups, with one death (4%) during hospitalization in the NIV group and seven (28%) deaths in the FM group (P < 0.04) Conclusion: Noninvasive ventilation compared with face mask alone prevented reintubation and decreased hospital mortality if done immediately after planned extubation in ICU patients requiring invasive mechanical ventilation for more than 3 days because of respiratory failure due to COPD.