الفهرس 
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Abstract
Objectives: to evaluate the macular vascular features (vessel density) of the eye of pediatric patients with sickle cell disease using optical coherence tomography angiography also optical coherence tomography to evaluate central macular thickness and ONH changes (retinal nerve fiber layer thickness).
Subjects and Methods: a case control study conducted on 15 sickle cell disease children and 15 age and six mathed children as control group. OCT-A was performed to all included children to assess macular vascular features (vessel density), central macular thickness and ONH changes (retinal nerve fiber layer thickness).
Results: There was a statistically significant thinning in the macular thickness and RNFL among SCD patients as compared with healthy population, CMT (267.26 ±17.39 vs. 283.42 ±12.53, p=0.001), RNFL (100.88 ±7.73 vs. 114.30 ±14.62, p=0.001), vessel density (VD) shows statistically significant reduction among the SCD children as compared with normal population, (44.70 ±4.92 vs. 46.46 ±3.13, p=0.035). There was a statistically significant correlation between age with VD (r=0.314, p=0.001), Hct value with RNFL thickness (r=0.419, p=0.003), RBCs count with CMT (r=-0.483, p=0.001), RBCs count with VD (r=0.479, p=0.001), and between CMT with RNFL thickness (r=0.199, p=0.047).
Conclusion: Our study in a pediatric sickle cell population showed a statistically significant thinning in the macular thickness (CMT) and (RNFL), and a statistically significant reduction in VD (%) among the SCD children as compared with normal population.
Keywords: Sickle Cell Disease (SCD), OCT-A, RNFL, CMT, VD (%).