الفهرس 
Title : Assessment of retinal and optic nerve microvasculture in Systemic Lupus Erythematosus patients using Optical Coherence Tomography Angiography
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Abstract
Purpose: The purpose of this study is to evaluate the changes of retinal and optic nerve microvasculture in systemic lupus erythromatosus patients with and without nephritis using vascular perfusion densities derived from optical coherence tomography angiography (OCTA) and to correlate the effect of the treatment on OCTA parameters. Design: This study is a cross-sectional, observational study. Methods: This study is a cross-sectional, observational study performed on individuals with SLE (66 eyes of 66 patients) and age-matched controls (33 eyes of 33 HC) imaged with a spectral-domain OCT system (XR Avanti, Optovue, Inc). A split-spectrum amplitude-decorrelation algorithm (SSADA) generated OCTA of the superficial retinal capillaries, deep retinal capillaries, and foveal avascular zone (FAZ). Vessel density values were compared with clinical staging, and groups were compared. Results: Systemic lupus erythematosus patients displayed a statistically significant decrease in microvascular retinal density in both superficial and deep layers compared to normal subjects (p value < 0.05). The vessel density in 300-om-wide region around the FAZ (FD-300) and the acircularity index (AI) were affected in the SLE in comparison to the normal group (P value < 0.05). Regarding this study, the FAZ (mean value ± SD) was found to be (0.36mm ± 0.06) for healthy controls, (0.29mm ± 0.09) and (0.28mm ± 0.10) for SLE with nephritis and without nephritis patients respectively