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Abstract Introduction :Wet cupping therapy is also known as Al-Hijamah in Arabic, meaning expansion, sucking, and bloodletting to return the body to its natural condition.Objective:The aim of this study was to determine the effect of cupping therapy versus manual therapy on patients with hypertension (HT) associated with irritable bowel syndrome (IBS), and its potential effect on Systolic blood pressure , Diastolic blood pressure , hemoglobin , pain and the subsequent improvement in their QoL. Methods: sixty patients of both sexes (men and women) had subjected to this study. They were selected from ministry of health and population hospitals in the period from May to August 2020. Their ages ranged from of 40-60 years old with mean age (53.6 ± 4.75). They were assigned into 2 equal groups. group A (30 pts) had been received manual therapy for three months, Three Manual Therapy massage sessions per week on back and abdomen for 12 weeks plus one session of wet cupping every month (3 sessions / 3 months). group B: (30 pts) had been received Three Manual Therapy massage sessions per week on back and abdomen for 12 weeks only. The data obtained indicated that, both groups were matched before the study with no significant differences between them (P>0.05). Results: In the study group (A) Systolic Blood Pressure decreases 11.4%{u2193}, also Diastolic Blood Pressure In the study group (A) decreases 12.3%{u2193}. but, In the study group (B) or Control Group, Systolic Blood Pressure decreases 2.9%{u2193}, also Diastolic Blood Pressure In the study group (B) decreases 2.8%{u2193}. In the study group (A) Hemoglobin count decreases 2.8%{u2193} but, In study group (B) Hemoglobin count increases 1.4%{u2191} In the study group (A) Pain decreases 58.5%{u2193} but, In study group (B) or control group Pain decreases 24.1% |