الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis is concerned with studying the binding interaction of tropisetron with bovine serum albumin by using several spectroscopic techniques and molecular docking simulation. The thesis consists of the following sections: Section I: Introduction It includes: I. An overview about plasma protein binding, bovine serum albumin, different approaches for studying plasma protein binding, and investigated drugs. II. Literature review about the method of analysis for tropisetron, and the previously published approaches for studying plasma protein binding interactions.Section II: Aim of the work I. IT includes the aim of this work and the basis on which the work has been done. Section III: Spectroscopic methods This section is divided into 2 parts Part1: Experimental Part2: Results and Discussion Which includes: UV absorption measurement, Fluorescence spectroscopy measurements,Synchronous fluorescence spectroscopy, FT-IR analysis |