الفهرس | Only 14 pages are availabe for public view |
Abstract The N-(p-substituted)propnamide derivatives 3a,b were obtained through the reaction of ethyl benzoyl acetate with either of aniline of 4-chloroaniline according the reported literature. The latter compound underwent a series of heterocyclization reactions to give thiophene, pyran and pyridine derivatives. The antitumor of the synthesized compounds against A549 (non-small cell lung cancer), H460 (human lung cancer), HT-29 (human colon cancer) and MKN-45 (human gastric cancer) cancer cell lines together with foretinib as the positive control by a MTT assay. Were measured. The results showed that some compounds were of high inhibitions |