الفهرس | Only 14 pages are availabe for public view |
Abstract Non-steroidal anti-inflammatory drugs are widely used for treatment of pain and inflammation, all classic NSAIDs inhibit COX-1 and COX-2, causing undesirable side effects such as gastric ulceration, altering platelet function and renal toxicity. Topical drug delivery systems are attractive routes for administration of NSAIDs, as they overcome gastrointestinal side effects and give local therapeutic effect. Lornoxicam, the drug of choice in this study, is a potent NSAID that belong to oxicams, it has short half-life, which require repeated uptake. In addition, lornoxicam has poor aqueous solubility leading to poor bioavailability |