الفهرس 
Outcome determinants in young adults with acute ischemic stroke with special concern to soluble cell adhesion molecules and prolactin: Clinical and laboratory study
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Abstract
Background : Studying outcome predictors in patients with onset of cerebral infarction in early adult life may enhance our knowledge of disease pathophysiology and prognosis. Aim: The aim to identify independent predictors of short-term outcome of first-ever ischemic stroke in young adults with special emphasis on cell adhesion molecules and prolactin. Methods: We enrolled 33 patients aged 19 - 44 years with first-ever ischemic stroke admitted to Kasr Alainy Stroke Unit and 33 matched controls. Clinical, radiological and laboratory (adhesion molecules, C-reactive protein, prolactin and mean platelet volume) evaluations were carried out. Functional outcome at 7 days after stroke onset was assessed using modified Rankin scale and independent predictors were identified. Results: The most frequently identified risk factor was cardiac abnormality. Patients exhibited significantly higher levels of baseline inflammatory and thrombogenic markers compared with controls. These markers were significantly correlated with the stroke severity. Logistic regression model showed that high National Institutes of Health Stroke Scale (NIHSS) score (odds ratios [OR] = 0.13; 95% confidence interval [CI], 0.04 {u2013} 0.24; P = 0.01) and large infarction size (OR = 0.11; 95% CI, 0.09 {u2013} 0.17; P =0.04) but not the laboratory markers were independent predictors of unfavorable outcome. Conclusion: Our data suggested that higher NIHSS scores and large infarction size served as independent predictors of short-term unfavorable outcome, while inflammatory and thrombogenic markers did not