الفهرس | Only 14 pages are availabe for public view |
Abstract Background: COX-2 expression is associated with MMP-2 expression in many cancers, suggesting that MMPs are linked to COX-2-mediated carcinogenesis. Several polymorphisms within the MMP2 promoter region have been reported in cases with oncogenesis and tumor progression, especially in colorectal carcinogenesis. Materials and Methods: This study was performed to assess the risk of COX-2 (A/G transition at -1195) (rs689465) and MMP-2 (C/T transition at-1306) (rs243865) SNPs with colorectal cancer in 100 patients and 100 healthy controls using Taqman Real-Time PCR |