الفهرس | Only 14 pages are availabe for public view |
Abstract 4-Aryl-1(2H)-phthalazinones attracted our attention due to its fame in constructions of various compounds with highly interesting pharmacological properties with clinical applications and have applications as new materials which used as switchable materials, sensors and inhibitors of metal corrosion. The present work dealt with study the nitration reaction of 4-aryl-1(2H)- phthalazinone derivatives under different conditions We are successful, for the first time, introduced the nitro group into the aryl group attached to C-4 of different phthalazinone derivatives through simple nitration reactions with good to excellent yields. The results showed that the most suitable catalyst was P2O5 at room temperature to introduce nitro group into the aryl group attached to C-4 of phthalazinone derivatives 1, 3-10, to form nitro phthalazinones 2, 13-20. In contrast, 4-halophenyl phthalazinone 11 and 12 derivatives gave a high yield of mono-nitrated products 21 and 22 using H2SO4 catalyst (scheme1). |