الفهرس 
Evaluation of serum uric acid and c-reactive protein levels in newly diagnosed immune thrombocytopenia patients and their correlation with platelets count
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Abstract
The pathophysiology of immune thrombocytopenia (ITP) is heterogeneous and complex. Pro-inflammatory cytokines such as IL-1, IL-6, and IFN-Þ leading to anti-platelet antibody production in patients with ITP. uric acid (UA) has been shown to be a mediator of inflammation via enhanced production of inflammatory cytokines IL-1Ý, IL-6. C- reactive protein (CRP) is produced by hepatocytes, in response to inflammatory cytokines such as IL-6 and IL-1. The main aim of this study is to evaluate the UA and CRP levels in 40 newly diagnosed ITP patients. As well as 40 age and sex matched healthy subjects as a control group. UA and CRP levels were found to be significantly higher in patients with ITP (P values {u02C2}0.001 and P values {u02C2}0.001 respectively). Moreover, UA levels were significantly positively correlated with CRP among the ITP patients (r = 0.380, p=0.001). Significant negative correlation were found between the platelet count and serum UA Levels (r = - 0.455, p {u02C2}0.001); CRP levels (r =-0.402 , p {u02C2}0.001); LDH level (r = - 0.320 , p = 0.044); ESR (r = - 0.366, p =0.020) in the ITP patients. In conclusion the present study showed that UA levels increased in patients with ITP and negatively correlated with platelet counts. UA levels might be a mediator of inflammation via enhanced production of inflammatory cytokines; they might also be a potential mediator of low platelet count