الفهرس 
Pharmacological and toxicological studies on calendula officinalis flower extract
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Abstract
Phytochemical, toxicological and pharmacological studies were carried out on calendula officinalis flower commonly used in folk medicine. Flowers different phytochemicals were analyzed. The calendula officinalis flower 70 % ethanolic extract toxicological studies (Acute and chronic toxicity) were investigated. The oral anti-inflammatory, antipyretic, analgesic, anticonvulsant, tranquilizing and hypnotic activities of Calendula officinalis flower 70% ethanolic extract were studied. Hepatoprotective, diuretic, healing, hormone like activity and effect of tested extract on male fertility were also investigated. Moreover calendula officinalis 70% ethanolic extract genotoxic, in vitro antibacterial and antispasmodic activities (on isolated rabbit{u2019}s duodenum) were analyzed. Phytochemical analysis of calendula officinalis flower revealed the presence of flavonoids, glycosides, tannin, saponins, resin and absence of alkaloids. calendula officinalis LD50 was 2450 mg / Kg b.wt. Prolonged administration of Calendula officinalis 70% ethanolic extract (12 weeks) produced significant increase in number of leucocytes, decrease in ALT and AST enzymes. Studied extract showed significant anti-inflammatory, antipyretic, analgesic, anticonvulsant, tranquilizing, hepatoprotective, diuretic, estrogen, progesterone, healing, antigenotoxic, antispasmodic and antibacterial activities