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Abstract from May 2013 to October 2015, we treated 20 patients (17 males and 3 females) with post-traumatic and post-infectious bone defect using Masquelet technique. Average age of 38 years (range: 12-64). Etiology of defect was open fractures in 6 cases (30%), infected nonunion in 11 cases (55%) and aseptic atrophic nonunion in 3 cases (15%). The mean size of bone defect was 7.2 cm. Soft tissue defect was present in three cases. In the first stage, thorough debridement wasdone followed by fixation and insertion of cement spacer. Second stage was done after 4 to 8 weeks with insertion of cancellous bone graft. Union occurred in 17 cases (85%) with a mean time of 7.4 months (range: 4 to 11) after second stage. 2 cases (10%) of graft resorption and 1 case (5%) of infected graft. In conclusion, induced membrane (Masquelet) technique is a safe, simple and reliable method for treatment segmental bone defect. The major complications of this technique include infection and graft resorption |