الفهرس | Only 14 pages are availabe for public view |
Abstract Aim: to compare the post-operative pain intensity following platelet rich plasma (PRP) revascularization in comparison to non-surgical root canal treatment procedures in mature necrotic mandibular molar teeth with randomized clinical trial. Methods: Twenty-eight patients were included. After confirming the diagnosis clinically and radiographically, In the first visit, teeth of both groups were instrumented using ProTaper Next rotary files. Double antibiotic paste (DAP) was prepared and injected then the cavity was temporarily sealed with glass ionomer. At the second visit, three weeks later, the patients were assigned according to the randomization either to control group where standard endodontic treatment was completed by lateral condensation technique with resin sealer for obturation or assigned to intervention group where PRP revascularization technique. The degree of spontaneous pain was measured using numerical rating scale (NRS) pre-operatively, then post-operatively after 6, 12 hours and daily for 5 days. Patients were given a placebo to be administrated in case of emergency and an analgesic (ibuprofen 400mg) was prescribed in case of persistent pain. Flare-up was considered if the patients reported moderate to severe pain and/or swelling that began 12 to 48 hours after treatment and lasted at least 48 hours. All demographic, baseline and outcome data were collected and statistically analyzedResults: Results showed that, regarding the post instrumentation pain there was no statistically significant difference concerning severity of pain in the two groups at all time intervals. While in the post revascularization / obturation pain there was no statistically significant difference between severity of pain in the two groups at all time intervals except after 12 hours. Revascularization group showed statistically significantly higher prevalence of no pain than endodontic treatment group (P-value = 0.041). Regarding the healing rate; there was no statistically significant difference between median lesion areas in the two groups pre-operatively, after 6 as well as 12 months at both mesial and distal roots. Conclusions:. Winthin the limitation of this study , It can be concluded that PRP revascularization reduces the postoperative pain of necrotic mature permanent mandibular molar teeth with chronic peri-apical periodontitis in comparison to the post-operative pain after conventional endodontic treatment The healing rate showed that there was no statistically significant difference between median lesion areas in the two groups pre-operatively, after 6 as well as 12 months at both mesial and distal roots so PRP revascularization could be a promising alternative to endodontic treatment in the treatment of necrotic mature permanent mandibular molar teeth with chronic periapical periodontitis |