الفهرس | Only 14 pages are availabe for public view |
Abstract The present study was designed to record the anti-RA effects and possible mechanisms of action of Ashwagandha roots extract on adjuvant induced multiple-joint arthritis in rat, an animal model of autoimmunity diseases with great similarities to rheumatoid arthritis. To investigate the therapeutic effects Ashwagandha roots extract on complete Freund’s adjuvant (CFA)-induced arthritis the following steps will be performed: -Determination of LD50 of extract -In vivo study to evaluate anti-inflammatory effect of tested extract The following parameters will be determined: 1 Clinical Scoring of Arthritis (paw volume) 2 Biochemical parameters Oxidative stress parameters Evaluation of cytokine Interleukin 1beta-, Interleukin 6 and TNF-α and COX1 and COX2 3 Histopathological studies: Histological sections for hind paw of experimental Animals. |