الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis comprises four chapters in addition to summaries in English and Arabic; The first chapter; General introduction which consists of a brief literature review of celecoxib and its analogues, in addition to an account on their cytotoxic activity. The second chapter; Recent advances in the development of celecoxib analogs as anticancer agents: A review. The third chapter; Design and synthesis of novel celecoxib analogues with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7. The fourth chapter; Design, synthesis, and biological evaluation of new celecoxib analogs as apoptosis inducers and cyclooxygenase‐2 inhibitors |