الفهرس | Only 14 pages are availabe for public view |
Abstract Benzoylacetone, Acetoacetanilide, and Ethyl benzoylacetate were used as key starting compounds which underwent a series of heterocyclization reactions to give Pyran, Pyrazole, Pyridine, Thiazole, Thiophene, and Aryl hydrazone derivatives. The multi-component reactions of the starting 1,3 diketones compounds with the aromatic aldehydes produced the pyran derivatives. The Gewald’s reaction of the 1,3 diketones with elemental sulfur and malononitrile or ethyl cyanoacetate yielded the thiophene derivatives, Evaluation of the synthesized products were carried against eight Cancer cell lines, A549 ( non-small cell lung cancer), H460 (human lung cancer), HT29 (human colon cancer), MKN-45 ( human gastric cancer), U87MG ( human glioma) and SMMC-7721 (Protein profile of human hepatocarcinoma) cancer cell lines together with Foretinib as the positive control by a MTT assay, while the HepG2 (Hepatocellular carcinoma) and HeLa (Cervical carcinoma) cancer cell lines together with Doxorubicin as the positive control, the most cytotoxic compounds against these cell lines were selected for further screening against other cancer cell lines. |