الفهرس Only 14 pages are availabe for public view
 |  | from | 229 |  |  |
| | | from | 229 | | |
Abstract
A new series of 2-heteroarylbenzimidazoleswere synthesized to study their antitumor activity. The starting material, 2-(furan-2-yl)-1H-benzo[d]imidazole was synthesized by a new method. Several substitutions were made in the nucleus through introduction of acid hydrazide group to position 1 of benzimidazole. Furthermore, several additions were made on the acid hydrazide forming schiff bases, oxadiazoles, tetrazoles, pyrazoles and other substituents. The antitumor activity of the new compounds was investigated against MCF-7 (breast cancer cell line).Moreover, the antiangiogenic capabilities of the synthesized compounds were tested against VEGF. AutoDock study has been done to identify the mode of interaction of entitled compounds into the VEGFR2 tyrosine kinase employing flexible docking approach for potential binding affinities of our novel analogs to find out their binding affinities and their orientation into the binding sites