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العنوان
Synthesis of some new heterocyclic compounds from enaminonitriles /
الناشر
Emad Samir Gergis Shehata ,
المؤلف
Emad Samir Gergis Shehata
هيئة الاعداد
باحث / Emad Samir Gergis Shehata
مشرف / Nadia Hanafy Metwally Mohamed
مشرف / Sayed Abdel Tawabe Ali
مناقش / Emad Samir Gergis Shehata
تاريخ النشر
2014
عدد الصفحات
136 P. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
30/5/2015
مكان الإجازة
جامعة القاهرة - كلية العلوم - Organic Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

The condensation of 2-cyanomethylpyrazolo[1,5-a]pyrimidines 3a,b with various aromatic aldehydes afforded the corresponding arylidene of substi- tuted pyrazolo[1,5-a]pyrimidines 5a-l. Coupling of compounds 3a,b with aryldiazonium salts led to formation of 2-arylhydrazono derivatives11a-j. Reaction of the latter compounds with malononitrile led to formation of polyfused heterocyclic compounds 15a-j.The reaction of 3a,b with phenyl isothiocyanate, followed by addition of Ü-haloketonesor Ü-haloesters afforded the polyheterocyclic compounds based-pyrazolo[1,5-a]pyrimidine derivatives. Also, the enamines of compounds 3a,b react with hydrazine derivatives to give the amniopyrazolo[4’’,3’’:5’,6’]pyrido[4’,3’:3,4]pyrazolo- [1,5-a]pyrimidine 28a-d. The structures of all the newly synthesized products were established by their elemental, spectral data and plausible mechanism has been postulated to account for their formation