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Abstract
UTI is a well-known common complication in pediatric renal transplant recipients, having many pre and post transplantation risk factors. UTI may cause significant morbidity and acute graft dysfunction although the impact of UTI on graft function is still unclear. Objective: to evaluate the frequency, risk factors, and impact of UTI on graft outcome in children post kidney transplantation.Results: Of the studied group twenty two out of fifty-four (40.3%) patients had UTI, 54% of UTI episodes were in the 1st 6 months. UTI was significantly higher in patients with history of UTI pre KTx (p=0.037). An association was found between post KTx UTI and the use of CNI immunosuppression (p=0.012 & 0.043 for Tacrolimus and Cyclosporine respectively). UTI was significantly higher in cases with post KTx VUR (p=0.001). There was no statistical association between post KTx UTI and induction immunosuppression or rejection episodes (BPAR) (p=0.620 and 0.211 respectively).As well, no association was found between UTI and low levels of GFR (p=0.198), however, still 45% of post KTx UTI cases have GFR< 60 ml/min/1.73m2 compared to 21% of non UTI cases with similar GFR. Conclusion: UTI was prevalent in pediatric KTx recipients, mostly during the first 6months post-Tx. History of UTI prior to Tx, CNI and VUR post KTx were significant risk factors. No direct relation was found between UTI and GFR although GFR levels tend to be lower (<60ml/min/1.73m2) in post KTx patients with UTI