الفهرس | Only 14 pages are availabe for public view |
Abstract Iron overload is frequently observed in patients with chronic hepatitis C (CHC) and is associated with the increased risk of liver fibrosis and carcinogenesis. Hepcidin is a regulator of iron homeostasis and a component of innate immunity. Based on previous studies iron overload might be a result of low hepcididin synthesis in CHC. Also, Vitamin D deficien»cy is very common (92%) among patients with chronic liver disease, and at least one-third of them suffer from severe vitamin D deficiency. Many reports showed the possible role of vitamin D supplementation in augmenting the response to SOC. The aim of this study was to assess hepcidin mRNA expression in liver tissue of patients with CHC before start of therapy as well as hepcidin and vitamin D serum levels at different periods of treatment. |