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Abstract
The pathophysiology of hepatic ischemia/reperfusion-induced insult (HIRII) includes a number of mechanisms that results in various degrees in the overall injury; but recently the role for glycogen synthase kinase-3Ý/Ý-catenin signaling in regulating HIRII apoptosis, proliferation, oxidative stress, and elevations of liver enzyme activities has been revealed. Thus, the present study was conducted to investigate the hepatoprotective effect of geraniol, an acyclic dietary monoterpene, on HIRII in rats. Geraniol (200 mg/kg) was orally administered for 14 successive days prior to HIRII. On the 15th day of geraniol administration, rats were subjected to 30 min partial hepatic ischemia (70%) of the portal triad followed by a 60 min reperfusion period. The HIRII elevated serum level of both aspartate and alanine aminotransferase activities, and hepatic nitroactive and oxidative stress biomarkers estimated as total nitrate/nitrite and thiobarbituric acid reactive substances. The latter event was associated by a reduction in the hepatic glutathione content. In addition, HIRII resulted in the elevation of glycogen synthase kinase-3Ý accompanied by the reduction of Ý-catenin and cyclin D1. These derangements were reflected as abnormal architecture of the liver aided by histopathological examinations. Geraniol alleviated HIRII-induced biochemical and histopathological alterations. In conclusion, the present results demonstrate a beneficial role for geraniol in ameliorating HIRII via its antoxidative- antinirtroactive activities, and stimulate proliferation by affecting the glycogen synthase kinase-3Ý /Ý-catenin signaling pathway