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Abstract
Background:Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of anti-platelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Aim: The current case-control study aimed at detecting the frequency of IL-1 Ra and DNMT3B gene promoter genes polymorphism in Egyptian ITP patients as genetic markers for ITP risk, and to clear out their possible role in the pathogenesis of ITP. Subjects and methods: Gene polymorphisms of IL-1 Ra and DNMT3B gene promoter were studied in 120 ITP patients and 120 healthy controls by PCR amplification of the target gene followed by allele specific restriction enzyme digestion (RFLP technique)