الفهرس | Only 14 pages are availabe for public view |
Abstract To evaluate the role of laparoscopic ovarian drilling (LOD) in changing the level of total testosterone hormone in patients with polycystic ovary syndrome (PCOS). Methods: It was performed by measurement of Serum level of total testosterone before and after 3 months of Laparoscopic ovarian drilling And also the decrease of serum level of total testosterone and the effect on ovarian reserve by measuring serum FSH after 3 months of Laparoscopic ovarian drilling in 40 infertile patients with PCOS resistant to induction by CC for 6 consecutive cycles, all patients were hyper androgenic before LOD. Forty patients from about seventy five patients were evaluated and diagnosed to have PCOS and by history, physical examination and investigations, and after getting the approval of ethical committee and took their consent . All patients were subjected for measurement of Serum level of: Total testosterone hormone and FSH before and after LOD, blood samples were taken from each patient were named sample A and B Sample A: was taken before LOD. Sample B: was taken 3 months after LOD. Timing of LOD: 2-3 days after the end of menstrual bleeding LOD was performed using diathermy probe pressed against the ovarian antimesentric surface performing 4-6 punctures on each ovary 4-5 mm apart through the ovarian cortex to a depth of 4-5 mm graduated on specific needle used for the procedure using coagulation current of 40 w . Then the ovaries were immediately cooled by raining with normal saline solution. Results: The total testosterone hormone was decreased after drilling with statistically highly significant difference in comparison to the level before . FSH was increased after drilling with statistically highly significant difference in comparison to the level before Conclusion: The laparoscopic ovarian drilling reduces the Total Testosterone Hormone level in patients with PCOS within 3 months of the procedure , which may fortify the chances of success of a subsequent induction of ovulation especially among clomiphene citrate resistant patients. |