الفهرس 
Epidemiology of migraine
Mitochondrial function and energy metabolism.Only 14 pages are availabe for public view
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Abstract
Migraine is a common disabling neurological disorder, much more common in females and typically starts in children and young adults. It is characterized by recurrent episodes of throbbing headache that have several recognized triggering factors. It is associated with several visual, autonomic,psychiatric,motor symptoms and may or may not be preceded with aura. The pathophysiology of migraine headache is complex and includes several mechanisms as CSD, hyperativity of the trigeminocaudal system, increased central excitability, mitochondrial dysfunction and the release of CGRP. The investigators have made a great progress in studying the pathophysiology of migraine, but the interaction between the various mechanisms have not yet been clearly understood. Studying the functional, metabolic and microstructural changes in the brain of migraine patients is very important for understanding the pathophysiology of migraine, development of therapeutic approaches and establishment of biological markers for diagnosis and follow up of the disease. Extensive research work has been carried out to study these changes, but the results are still controversial. So this work was carried out to study the functional, metabolic and microstructural changes in the brain of migraine patients. The study was carried out in the Neuropsychiatry and Radiology departments in Tanta University Hospitals in the period from 1st of December 2019 till the end of April 2022. The study included 42 migraine patients without aura (11 males and 31 females), diagnosed according to the criteria of the 3 beta version of the International Classification of Headache Disorders published in 2013, and 11 age and sex matched healthy controls (3 males and 8 females). Exclusion criteria included the detection of evidence for any pathological condition that may affect the examined brain changes in addition to intake of migraine prophylactic treatment within the last three months before examination. Patients were examined three days or more away from the migraine episode. All patients and controls were subjected to the following 1. Detailed history taking with emphasis on headache features 2. Thorough neurological and general examination.