الفهرس 
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Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with high heterogeneity that predominantly affects women, especially those of reproductive age (Mok et al.,2018).
SLE is characterized by autoantibody formation against nuclear antigens with resultant inflammation in organs such as the kidney, skin and joints. SLE is notorious for its markedly heterogeneous clinical phenotype, with a multifactorial etiology that depends on genetic, epigenetic and environmental influences (Tsokos et al ., 2011).
The aim of this study was to demonstrate the correlation between MPV, PDW,NLR,PLR and lupus activity by SLEDAI as disease activity score.
This study was conducted on 120 clinically diagnosed SLE patients (60 active disease and 60 inactive disease ) with follow up of patients with active disease after 6 months of treatment and 120 healthy controls.
The patients were diagnosed according to 2019 EULAR\ACR classification criteria for systemic lupus erythematosus.(Ann Rheum Dis, 2019) All were subjected to full clinical history and examination, complete blood count, ESR, CRP , ANA , Ds DNA , C3, C4,liver enzymes serum creatinine ,uric acid , Complete urine analysis ,24 hours urinary protein and renal biobsy in some patients.
Renal Biopsy was done in some patients and classified according to the to the classification of lupus nephritis by the International Society of Nephrology/Renal Pathology Society (ISN/RPS) (Weening et al.,2004).
This study demonstrated the following:
• The MPV was lower among cases than control , and lower among active cases than inactive cases and follow up.
• The PDW, NLR ,PLR was higher among cases than control and higher among active than inactive and follow up.
• SLEDAI score was higher in cases than control, and higher among active than inactive and follow up.
• ESR, and CRP were significantly higher among cases than controls, and among active than inactive and follow up .
• MPV was negatively correlated with the SLEDAI score and ESR.
• The PDW, NLR ,PLR were positively correlate with the SLEDAI score and ESR.
• NLR was higher in patients with lupus nephritis.