الفهرس | Only 14 pages are availabe for public view |
Abstract Abstract Corn silk (CS) has been used successfully in the traditional management of diseases that are associated with oxidative stress mainly diabetes and diabetic complications such as diabetic nephropathy. The current study aimed to investigate the protective effect of CS powder (CSP) against diabetic nephropathy. Thirty male Wistar albino rats were randomly divided into five groups (n = 6) as follow; -ve control group fed basal diet, +ve control group fed basal diet and injected with a single dose of Alloxan to induce diabetes. Groups 3-5 as the same of group2 but fed on basal diet containing 2.5, 5 and 10% CSP. Results revealed that CSP caused a significant decrease in blood glucose level, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), urea nitrogen, uric acid, creatinine, aspartate transferase (AST), aminoalkanoic acid transferase (ALT) and malondialdehyde. In addition, CSP caused a significant increase in insulin level, high-density lipoprotein (HDL) and catalase, especially in group 5 which treated with10% compared to other treated group +ve control group. Furthermore, CSP caused marked renal and pancreas improvement for damaged that happened due to Alloxan as revealed by alterations in histopathological architectures of kidney and pancreas tissues. In conclusion, CSP protect rats against Alloxan diabetic nephropathy through its antioxidant, anti-apoptotic, and anti-inflammatory protective mechanisms. So, it may be beneficial to the human beings. Key Words: Corn Silk, Rats, Diabetic Nephropathy |