الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Chronic pancreatitis is a progressive disorder resulting in destruction and fibrosis of the pancreatic parenchyma which ultimately leads to impairment of the endocrine and exocrine functions with a significant impact on the physical, social, and psychological wellbeing. Moreover, the patients are at an increased risk of morbidity from complications such as malnutrition, diabetes, and pancreatic cancer. Pain management and supportive care are the only current therapies existing for ChP patients with no specific treatment modality available for halting the progression of the disease, mostly due to an incomplete understanding of its underlying mechanisms and pathogenesis. Therefore, it is important to find proper animal models to characterize the events of this disease and to test new treatment modalities. Intra peritoneal administration of a high dose of l-arginine in rats is considered a non-invasive model that produces selective, dose-dependent acinar cell necrosis.
MSCs are thought to have a protective role mediated through their paracrine secretion of growth factors, having antiapoptotic, immunoregulatory, and angiogenic functions. Taurine is a free beta amino acid that is normally present in high concentrations in many tissues of human and animal species. The antioxidant and inflammatory properties have been shown in many experimentally induced inflammatory conditions.
This study aimed to experimentally induce chronic pancreatitis via I.P. injection of l-arginine and to investigate the possible therapeutic role of BMSCs and taurine supplementation alone or in combination in the treatment of the induced chronic pancreatitis.
Six male Sprague Dawley albino rats were used to obtain the bone marrow from their long bones. Also, forty-five virgin female Sprague Dawley