الفهرس | Only 14 pages are availabe for public view |
Abstract ral ulceration of any portion of the gastrointestinal tract (GI), most often affecting the terminal ileum and colon. Diagnosing IBD requires a combination of clinical findings, inflammatory, laboratory markers, endoscopic examination and histopathological evaluation. Tumor necrosis factor-alpha is a pleiotropic immune cytokine belonging to the TNF superfamily of receptor ligands. It is involved in several homeostatic and inflammatory processes, and plays a major role in autoimmune and inflammatory diseases like inflammatory bowel disease. Vitamin D plays a role in the immune responses by influencing macrophages and T lymphocytes and also repairs the intestinal mucosal barrier. People with IBD are likely to be at increased risk of developing vitamin D deficiency for a number of reasons including: impaired absorption of nutrients and bile salt malabsorption, restricted dietary intake, and medical advice to avoid/protect against sunlight exposure while taking immunosuppressive treatments such as thiopurines. Various studies reported the role of vitamin D in IBD. Vitamin D deficiency may lead to a reduction in bacterial clearance in the colon. We aimed at this study to evaluate the role of tumor necrosis factor alpha and vitamin D in activity and severity of inflammatory bowel disease in Egyptian patients. This study was conducted on 62 IBD (UC and CD) naïve patients and 31 normal persons from the GI endoscopy unit of Internal Medicine Summary - 122 - Department, Menoufia University hospital during the period between November 2021 and November 2022. The participants (who were indicated for Colonscope) were classified into 3 groups group (1): Ulcerative colitis patients including 31 participants group (2): Crohn’s disease patients including 31 participants group (3): Control group resemble normal persons including 31 participants All participants were subjected to the following: History taking including age, gender, special habits (smoking), residence, consanguinity and family history. General examination including vital signs and anthropometric measures Clinical data as abdominal pain, diarrhea, and number of bowel motions, presence of abdominal masses, rectal bleeding and presence of extra intestinal manifestations. Routine lab investigations including CBC, ESR, LFTs, KFTs ,CRP and fecal calprotectin. Serum Vitamin D level and TNF alpha level measurement. Colonoscopy examination. This study showed highly significant difference between studied groups as regard serum vitamin D level with low level of vitamin D in IBD patients. This study showed no significant difference between disease activity and serum vitamin D level. This study also showed highly significant difference between studied groups as regard serum TNF alpha level with no significant difference between studied groups as regard disease activity and serum TNF alpha level. |