الفهرس | Only 14 pages are availabe for public view |
Abstract Systemic hypertension induces a progressive increase of left ventricular (LV) mass with subsequent LV hypertrophy (LVH) with resulting derangement of LV function. The interaction between left ventricle (LV) and arterial system, termed usually ventricular-arterial coupling, and is recognized nowadays as a key determinant of global cardiovascular performance. The ventricular-arterial coupling is commonly calculated by the ratio of effective arterial elastance (EA), a measure of afterload, to LV endsystolic elastance (EES), a relatively load independent measure of LV chamber performance. LV and arterial system are optimally coupled to produce stroke work, The ventricular-arterial coupling has independent prognostic value in patients with arterial hypertension. Assessment of VAC via EA/EES, noninvasively can be used for risk stratification of patients with hypertension. LV deformation as strain can be used for early detection and quantification of myocardial dysfunction of different etiologies We aimed in this study to assess the effect of hypertension on left ventricular mechanical & Ventricular-arterial coupling by using Speckle tracking imaging technique. The study conducted on 75 hypertensive patients and 25 control subjects, Echocardiography performed using a Vivid E9 ultrasound and Conventional ECHO was done (2D- M mode – Doppler study) for all participants. The present study assessed left ventricular peak systolic strain in hypertensive patients and controls and found that there was significant lower between hypertensive patients and controls as regards all parameters of left ventricular peak systolic strain. Hypertension increase left ventricle & arterial stiffness led to changes in left ventricular mechanism which are correlated decrease the Global longitudinal strain. |