الفهرس 
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Abstract
Introduction: Sepsis is the presence of life-threatening organic dysfunction caused by a dysregulated response of the body to infection. Early diagnosis of sepsis is essential for reducing the high morbidity and mortality rate in these patients. suPAR is the soluble form of the urokinase-type plasminogen activator receptor. The aim of the work: The aim of this study is to evaluate the value of soluble urokinase plasminogen activator receptor in cases of sepsis in ICU adult. Patients: ICU adult patients attending the specialized medical hospital, Mansoura University. in the period from January 2022 to January 2023. This was a prospective case-control study that was conducted on 45 subjects: 40 ICU adult patients with sepsis, in addition, 15 apparently healthy individuals with matched age and sex were selected to serve as control group. Methods: All participants of the study were subjected to full history taking, clinical examination and routine investigations. Serum soluble urokinase plasminogen activator receptor level was measured by ELISA method. Two samples were taken from sepsis patient, first sample at time of diagnosis with positive blood culture and second sample after 3 days of starting antibiotic therapy. Results & Conclusion: As regards serum level suPAR at the diagnosis, there was significant elevation of suPAR in sepsis group compared the control group. And also by comparison of CRP, TLC and suPAR at diagnosis and at 3rd day of antibiotics among survivors and non-survivors we found that TLC at 3rd day of antibiotics, suPAR at diagnosis and suPAR at 3rd day of antibiotics were significantly elevated in non-survivor group compared to survivor group. TLC and CRP were significantly reduced in 3rd day of antibiotics compared to diagnosis in survivor group. Recommendations: In the view of the present study, the following recommendations could be taken into consideration: routine use od suPAR as a method of prediction of mortality in septic patients. Further studies are required for a satisfying understanding of the biochemical properties and regulatory mechanisms of suPAR in critical disease in order to evaluate whether suPAR could also be a potential novel therapeutic target in critically ill patients. Further studies with larger sample size are needed needed to elucidate the validity of suPAR levels in both the diagnosis and prediction of mortality in septic patients.