الفهرس 
VENTILATOR-ASSOCIATED PNEUMONIA IN CHILDREN (VAP)Only 14 pages are availabe for public view
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Abstract
ABSTRACT
Background TREM‑1 (setting off receptor imparted on myeloid cells‑1) is an immunoreceptor. Neutrophils, mono‑ cytes/macrophages, and endothelial cells all express TREM‑1. This work aimed to evaluate the role of STREM‑1 in ventilator‑associated pneumonia (VAP) early prediction in pediatrics.
Methods This case–control research involved 56 children aged from 1 month to 5 years old, who were admitted to the pediatric intensive care unit (PICU) and needed mechanical ventilation (MV), from January 2023 to June 2023. Subjects were equally allocated into two groups: VAP group and non‑VAP group.
Results There was significantly elevated serum STREM‑1 after 72 h than at admission between both groups. There was significantly elevated STREM‑1, procalcitonin (PCT), and C‑reactive protein (CRP) after 72 h in the VAP group com‑ pared to the non‑VAP group. There was a positive correlation between PCT and CRP after 72 h. STREM‑1 at admission and after 72 h area under the curve (AUC) was 0.641 (0.502 to 0.765), 1.000 (0.936 to 1.000), with best cut‑off value for prediction of VAP was > 185, > 230 with sensitivity 53.6%, 100% and specificity 67.9%, 100%, respectively.
Conclusion Serum sTREM‑1 concentration is a reliable biomarker for predicting VAP in pediatrics received MV.