الفهرس 
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Abstract
The current study was conducted at Endocrinology Unit in Department of Internal Medicine at Assiut University Hospitals. It was conducted in the period between 2021 and 2022. The study enrolled a total of 142 patients with type 2 diabetic patients. The study aimed to evaluate the association of serum uric acid level with metabolic risk factors in patients with type 2 diabetes and their relation to estimated glomerular filtration rate status.
Mean age of the studied patients was 61.08 years. Out of the studied patients; 77 (54.2%) patients were males. Based on level of serum uric acid; 46 (32.4%) patients had normal serum uric acid and 96 (67.6%) patients had high serum uric acid. Sixty-nine (48.6%) patients had normal estimated glomerular filtration rate and 73 (51.4%) patients had reduced estimated glomerular filtration rate. A total of 60 (42.3%) patients had metabolic syndrome.
The main findings in the study were;
- Patients with high serum uric acid had significantly higher frequency of hypertension and chronic kidney disease. Also, patients with high serum uric acid had significantly higher frequency of metabolic syndrome and reduced estimated glomerular filtration rate
- Patients with high serum uric acid had significantly higher cholesterol (201.77 ± 54.44 vs. 157.87.22 ± 43.34 (mg/dl), triglycerides (121.45 ± 25.25 vs. 99.11 ± 13.54 (mg/dl)) and low-density lipoproteins (122.11 ± 24.44 vs. 91.22 ± 7.89 (mg/dl)) with significantly lower high-density lipoproteins (27.01 ± 4.44 vs. 39.33 ± 11.11 (mg/dl)).
- Patients with reduced estimated glomerular filtration rate had significantly higher of mean serum uric acid (8.26 ± 2.34 vs. 4.23 ± 0.87 (mg/dl)) with higher frequency of high serum uric acid (79.5% vs. 55.1%; p< 0.001) and MetS (54.8% vs. 28.9%; p< 0.001) in comparison to those with normal estimated glomerular filtration rate.
- Serum uric acid had positive significant correlation with number of metabolic syndrome criteria, serum creatinine, cholesterol, low density lipoproteins and triglycerides. Meanwhile, it had negative significant correlation with estimated glomerular filtration rate and high-density lipoproteins.