الفهرس 
Grading of papillary urothelial neoplasiaOnly 14 pages are availabe for public view
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Abstract
Rising evidences suggest that cancer progression is highly affected by the host immune response, which is represented by immune cell infiltrates. The distribution of (CD3+) T lymphocytes and cytotoxic T lymphocytes (CD8+) have been used to establish an Immunoscore (IS), which is reported to be a reliable prognostic factor in colon cancer, but its significance in bladder urothelial carcinoma is at an early stage of exploration.
Aim of work: The aim of this work is to correlate IS in urothelial carcinoma with different prognostic clinicopathologic parameters, to examine its prognostic validity and possible role in bladder urothelial carcinoma prognostic prediction.
Materials and method: Forty cases of archived paraffin sections from patients diagnosed with bladder invasive urothelial carcinoma underwent radical cystectomy, collected from Nasser institute for treatment and research. Cases were stained for CD3 and CD8 immunohistochemical stains, CD3+ and CD8+ cells were measured in tumor center and invasive margin, and counted using the image analysis system in pathology department, National research center. The correlations evaluated between IS and clinical and histopathological parameters of urinary bladder carcinoma.