الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
Angiotensin converting enzyme (ACE) is a crucial enzyme in renin angiotensin aldosterone system (RAAS), having a pivotal role in blood pressure regulation. Despite its widespread medical applications in hypertension, heart diseases, diabetic nephropathy, and many others, inhibitors of the ACE enzyme suffer from different side effects that limit their use. Plants and natural products are the primary sources of renewable natural compounds that could act as potential leads for different ailments. The following study represents the identification of ACE inhibitors from carefully selected edible plants through adopting combined in silico techniques with biological testing. Molecular docking studies were performed on 1526 phytoconstituents present in 19 edible plants. Biochemical testing of extracts from the top ten hit plants revealed that Moringa oleifera is a potent ACE-1 inhibitor with an IC50 value of 104.4 μg/mL. On top of that, its isolated compound 4-O-caffeoylquinic acid had IC50 value of 62.92 μM. In silico combination analysis showed synergistic effects of moringa extract and 4-O-caffeoylquinic acid combined with captopril, especially at 90% effect level. This, in turn, is likely to reduce side effects and toxicity. Furthermore, selective domain.