الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: Inferior turbinate hypertrophy is a common cause of nasal obstruction. It is mostly because of allergic and non-allergic rhinitis. Medical treatment is the first line of management, while surgery is done only for cases not responding to medications. It is important to understand the pathophysiology of the turbinate and its structure to choose the most appropriate technique for reduction of hypertrophied inferior turbinate. The hypertrophied turbinate is composed of bony part covered by mucosal part in varying degrees. Some are mostly mucosal, and others are mainly bony. Platelet-rich fibrin (PRF) is a second-generation platelet concentration that activates wound healing through increased fibroblast and growth factor. Aim of the study: The aim of our study is to assess the effect of PRF to cover the surgical site after ESMR for inferior turbinate hypertrophy. Methods: This prospective cohort study was conducted in Otolaryngology- Head and Neck Surgery Department, Mansoura University Hospitals, Egypt, over 1 year duration on 60 patients with inferior turbinate hypertrophy of mixed type. Informed written consents were obtained from all participants, and the study was approved by the Mansoura Faculty of Medicine Institutional Research Board. Results: In the current work, Assessment of postoperative crustation showed statistically significant differences between both groups at 1st and 3rd week postoperatively, with less crustation grades detected in PRF group. However, no statistically significant differences were seen at 12th week postoperative. Assessment of postoperative healing showed statistically significant differences at 1st and 3rd week between the two groups with better healing seen in the PRF group. However, no statistically significant differences were seen at 12th week, postoperatively. Conclusion: The current study concluded that the novel use of PRF after ESMR in patients with bilateral ITH of mixed type accelerates wound healing by rapidly creating healthy granulation tissue. Growth factors derived from platelets play an important role in tissue modelling including neovascularization. As a result of the effects of PRF on wound healing, better outcomes were obtained in terms of decreased postoperative nasal obstruction and crustation and increased degrees of healing process in PRF group after ESMR. The application of PRF is an inexpensive and easy procedure Keywords: ITH · ESMR · PRF