الفهرس 
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Abstract
The skin is the largest organ in vertebrates, it covers the whole surface area of the body and accounts for 15% to 20% of body mass. It is very important in the defence against infections and in allergic responses. A wound is a disruption of the skin’s natural anatomical structure and functional integrity. Non-healing wounds are a significant public health issue and a significant financial drain on the healthcare system. Serious problems including amputation in cases of diabetic foot ulcers, scarring and deformity from burns, and life-threatening functional disability are all related to non-healing wounds.
Platelet rich plasma (PRP) is an endogenous therapeutic technology. It has the capacity to preserve normal tissue structure and heal tissue damage as it is rich in several cytokines and proteins necessary for wound healing. Bone marrow- derived mesenchymal stem cells (BM-MSCs) can develop into a variety of cell types. BM-MSCs release various trophic factors that control inflammation and remodelling, so they aid in wound healing.
The aim of the present work was to assess the possible morphological, histological and immunohistochemical effects of PRP and/or BM-MSCs on cutaneous wound healing in a diabetic rat model.