الفهرس 
Introduction and RationaleOnly 14 pages are availabe for public view
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Abstract
Thalassemia is an autosomal recessive blood disorder and one of the most common hemoglobinopathies in the world. Lifelong frequent blood transfusions are recommended for transfusion-dependent thalassaemia. The human body doesn’t have a physiological mechanism for elimination of excess iron load following blood transfusion. Iron overload causes a variety of functional alterations in the human body. Excess iron accumulates particularly in the liver, heart, and endocrine organs. Diabetes mellitus is considered the third commonest endocrine complication. Although the exact mechanism of iron-induced diabetes is unknown, three major processes are believed to play a role in its development, insulin resistance, insulin insufficiency, and hepatic dysfunction. The goal of this study was to determine the frequency of glycemic abnormalities i.e. Diabetes Mellitus and insulin resistance in patients attending Hematology outpatient clinic of Suez Canal University Hospitals. The objective of this study was to asses the relation between iron overload and glycemic abnormalities in thalassemic patients and To detect factors affecting glycemic abnormalities among thalassemia patients with early detection of glycemic abnormalities in patients with thalassemia to prevent its complications and start early and proper management. This study is an analytical cross-sectional study conducted over 67 patients attending the hematology outpatient clinic of Suez Canal University Hospital, Ismailia, Egypt, in the period between March 1 and June 10, 2022. Additionally, patients included were all thalassemic patients of either sexes aged more than 12 years old with exclusion of type 1 Diabetes Mellitus patients and chronic liver disease