الفهرس | Only 14 pages are availabe for public view |
Abstract Benign prostatic hyperplasia (BPH) is a frequent cause of LUTS in men. Both active and passive forces in the prostate tissue have a role in the pathophysiology of BPH. The adrenergic nervous system has been reported to regulate active smooth muscle tone. Alpha1-blockers inhibit contraction of smooth muscle in the prostate and reduce prostate tone and BOO. Alpha -blockers are the drugs of choice for LUTS secondary to BPH. Alpha 1-adrenoceptors are divided into three subtypes α 1a, α 1b, and α 1d. The current study evaluated the efficacy and safety of single versus double dose of tamsulosin 0.4 mg for treatments of moderate and severe LUTS/BPH and effect on IPSS, Uroflowmetry and PVR at 3 times intervals. Total IPSS was more decreased (improved) in double dose tamsulosin 0.4 mg group than single dose tamsulosin 0.4 mg group, with P-value = 0.005 at one month follow up and 0.007 at three months follow up, which is statistically significant difference. Dizziness was more frequent in double dose tamsulosin 0.4 mg group than single dose tamsulosin 0.4 mg group, with P-value = 0.03 at one month follow up and 0.01 at three months follow up, which is statistically significant difference. |