الفهرس | Only 14 pages are availabe for public view |
Abstract Vitiligo is an acquired , progressive , multifactorial, depigmenting disorder characterized by the appearance of circumscribed white macules in the skin due to chronic progressive loss of functioning melanocytes in the epidermis.Multiple hypotheses have been proposed to clarify the etiology of vitiligo, including genetic,cytological,immunological,neurological,impaired antioxidative defense and environmental destruction of the melanocytes. However, there is strong evidence that vitiligo is mainly an autoimmune disease, because of its association with other autoimmune diseases, anti-melanocytes and other organ-specific autoant ibodies.Cathelicidin an antimicrobial polypeptide, is an important part of innate immune system. It has anti-inflammatory and pro-inflammatory effects. There is a possible role of cathelicidin in autoimmune and inflammatory diseases, such as inflammatory bowel diseases, RA and systemic lupus erythematosus (SLE). Also altered level of cathelicidin was noticed in some chronic cutaneous disorder such atopic dermatitis,psoriasis and rosace |