الفهرس 
Beta ThalassemiaOnly 14 pages are availabe for public view
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Abstract
Beta-thalassemia major is the most common genetic disorder of
hemoglobinopathies which characterized by reduced or absent
production of the beta-globin chain that results in ineffective
erythropoiesis which results in chronic hemolytic anemia and blood
transfusion dependency for life due to unavailability of curative
treatment with stem cell transplantation as there are limitations in
suitable donors and cost leading to iron over load in different body
systems.
Recent studies have found that the pathogenesis of diabetes
mellitus is related to the defects of insulin secretion caused by iron
overload which damaging pancreatic beta cells.
Value of HbA1C, serum fructosamine, and serum glycated
albumin (GA) remains controversially in monitoring glucose
dysregulation in relation to iron overload in children with beta
thalassemia major.
This study aimed to assess the risk of blood glucose
dysregulation and its relation to iron overload in Egyptian children
and adolescents with beta thalassemia major.
This was a case control study and was carried on adequate
number of Egyptian children and adolescents divided on two groups:
group 1: patients with beta thalassemia major were enrolled
from Pediatric Hematology and Oncology Unit, Menoufia
University Hospital.
group 2: healthy children and adolescents of matched age, sex
and socioeconomic standards as control.
The results of the present study can be summarized as
follows:
There were no statistically significant difference between
patient group and control group regarding age (years). In patient
group; 59% of them were males and 41% were females.
There was highly statistically significant difference between
control group and patient group regarding height and weight,
and there was statistically significant difference between control
group and patient group regarding BMI.
There was highly statistically significant difference between
control group and patient group regarding FPG, fasting insulin,
HOMA-IRI, 2-h post prandial plasma glucose and HOMA-ISI.
Regarding FBG, normal were 49 (49.0%) in patient group and
87 (87.0%) in control group, Impaired fasting glucose tolerance
was 32 (32.0%) in patient group and 13 (13.0%) in control
group, more diabetic was 19 (19.0%) in patient group and 0
(0.0%) in control group.
The average serum ferritin (μg/l) among last 6 months in patient
group was; 1958.37 ± 963.16 in euglycemic group and 3129.41
± 785.89 in glucose dysregulated group, there were 35 (71.4%)
cases in euglycemic group were improving serum ferritin with
chelation therapy in patient group and 21 (41.2%) in glucose
dysregulated group.
Male were (64.7%) in glucose dysregulated group but with no
statistically significant difference between euglycemic group
and glucose dysregulated group regarding sex.