الفهرس 
? Prostate Cancer: Prevalence, Risk Factors, and ImpactOnly 14 pages are availabe for public view
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Abstract
Background: GA-68 PSMA PET/CT is a cutting-edge imaging technique that has significantly improved the diagnosis and management of prostate cancer. It utilizes a PSMA-ligand radiotracer, which has shown promising results in accurately staging primary prostate cancer and restaging after biochemical recurrence. The technique combines functional and morphological information, providing a higher diagnostic accuracy compared to conventional imaging modalities like CT or MRI.
Objective: To evaluate the diagnostic accuracy of 68Ga-PSMA PET/CT in the staging and follow up in patients with prostatic malignancy.
Methods: This prospective diagnostic accuracy study was conducted in radiology department of Ain Shams University hospitals within 18-24 months on thirty males aged > 50 years old either symptomatic or asymptomatic with suspicious clinical results by digital rectal examination (DRE) and/or total PSA (tPSA) of > 4 ng/ml, referred for radiological evaluation in radiology department of Ain Shams University hospitals will be eligible for enrollment.
Results: The total PSA was found to be significantly different among Gleason grade groups as the higher the Gleason grade group the higher the average of total PSA. Also, there was a medium positive correlation between total PSA and SUVmax and this correlation is statistically significant. Moreover, the regression model was statistically significant and it showed that when the total PSA increased by 1ng/ml, the SUVmax significantly increased by 5.23 which means that 39% of the variation in SUVmax can be explained by the variation in total PSA and this also applies to PSA density. There was also a significant difference in the distribution of nodal mets categories under different Gleason grade groups where lower grade groups has lower percents of the positive nodal mets and we go up through the grade groups the percent of nodal mets increased significantly among patients which means that the variation in nodal mets can be explained by the variation in grade groups.
Conclusion: Ga-68 PSMA PET/CT parameters can improve the clinical outcome and help in treatment plans.