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Abstract In this work, 20 caeee with hepatosplenic schis-tosomiasis were selected at random; 10 cases were aecitic and 10 oases were non ascitic. All cases were subjected to various clinical, biochemical and electrocardiographic studies: All patients were given oral calcium, intravenous calcium gluconate and vitamin D. Serum calcium determination and E.C.G. were done to all patients before and after every type of therapy.Oral calcium intake was found to have no signifi¬ cant effect on raising the serum calcium in both groups non ascitic and aecitic. Intravenous calcium injection was followed by non significant decrease in the serum calcium level in either groups non ascitic and ascitic. This decrease may be attributed to: li Buffering action of bone to extracellular fluid ,- mineral content and calcium homeostasis. 2. The release of calcitonin hormone, which is a :r calcium lowering hormone, with its subsequent ^ effect on serum calcium level. |