الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Cirrhosis has been known to be associated with a hyperdynamic circulation for the past 50 years, manifesting primarily as increased cardiac output and decreased systemic vascular resistance. More recently, cardiac structural and functional abnormalities have also been described in both pre-ascitic and ascitic cirrhotic patients of alcoholic and non-alcoholic etiologies. These include hypertrophy of the myocardium, leading to a stiffer ventricle and hence diastolic dysfunction, and normal systolic function at rest but systolic incompetence under conditions of stress. This constellation of abnormalities has been termed ”cirrhotic cardiomyopathy”. The aim of this study is to investigate the relationship between liver cirrhosis and systolic, diastolic and conductive cardiac functions in children. Our study included 20 children (age 10.083.26 years) with established post hepatitic cirrhosis as evidenced by liver histopathology. 11 normal children of matched age and sex are enrolled in the study as control group. All the patients are subjected to the following: 1) Thorough history and physical examination. 2) Abdominal Ultrasonargraphy. 3) Serum Albumin, Bilirubin and Prothrombin time. 4) 12 leads ECG: for QTc interval. 5) Echocardiography for systolic and diastolic cardiac functions. 6) Stress test: to assess cardiac response to exercise. After statistical analysis to the previous data we reached to the following results: 7) The cirrhotic children have hyperdynamic circulation 8) The LV mass is significantly higher in cirrhotic children. 9) LV wall stress is significantly higher in cirrhotic patients. 10) Systolic dysfunction: FS is significantly lower in class A and class B Child’s classification versus controls. 11) Diastolic dysfunction: E wave and DT is significantly decreased in cirrhotic children versus control group. 12) Conductive dysfunction: Significant prolongation in QTc in cirrhotic patients. 13) Exercise intolerance.