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Abstract This research was conducted to study the effect of using the drug Cyclophosphamide , which is used as a chemical treatment for the body and tumors of the immune system inhibitor on the salivary glands underneath the jaw mice. And Make Hmaseat at ninety - six male fugitive from under a unified feed barley consisted of coarse , dry milk , along with some vegetables and carrots with drinking water as needed. The mice were divided into two main groups numerically equal (each forty - eight Vara ). Group first officer and second trial . In each major group divided the mice into four groups (the number of each twelve Vara ) vary age- to two weeks and four weeks, six weeks, eight weeks so as to inject control groups trying to Salt normal ( physiological ) and injected experimental groups drug Cyclophosphamide dose of 75 mg per kilogram were injection within membrane protein for each var. To study histological and Alhustokimaaúah were divided mice in each group , whether an officer or a pilot into four subsets equal Aadidia (each with three mice ) to Veh mice and getting sliced histologic day after a week and fifteen days and thirty days of the injection. Has been used in this research Sbah Alheimatoxlin Eocene and histological study. To study Alhustokimaaúah of it has been used in this research: - Frozen sectors for detecting enzymatic activity of acid and alkaline phosphatase . - Paraffin sectors dyed dyes following : 1. Chef solution and acid Alberoaodik after treatment slides. 2. Alalchian blue. 3. Broome phenol mercurial blue to detect protein. * The search returned the following results: 1 - Clinical results : - Lack of weight and size mice Altjeribbah the comparing the control mice. - Hair loss in experimental weeks. - The presence of swelling in the salivary glands of the experimental mice. 2 - histological results : The study showed histological paraffin sectors dyed dye Alheimaoudi and Eocene from bad influence to drug Alsakulovsampd on the salivary glands underneath its jaws. The study concluded : That the property Alsakulovosagamed effect bad on the salivary glands underneath the jaws in mice therefore recommend that detects strict medical at the mouth and teeth of patients described their use of this drug and dental treatment infected caries and treatment of gum infections before the start of treatment , which may increase the change in salivary glands and their secretions because of this drug. |