الفهرس | Only 14 pages are availabe for public view |
Abstract Acute renal failure is characterized by a deterioration of renal function over a period of hours to days, resulting in the failure of the kidney to excrete nitrogenous waste products and to maintain fluid and electrolyte homeostasis. ARF may be divided into three categories; prerenal, intrarenal and postrenal, which account for 30<U+2013>60%, 20<U+2013>40% and 1<U+2013>10% of cases, respectively. The study was preformed on 63 patients presenting with the manifestation of acute renal failure in the period from January 1999 till December 2004. Fifty patients were inpatients in Mansura University Children Hospital. Thirteen cases were adults referred from different centers to the pathology lab. In children, the cause of ARF in our study were Acute glomerulonephritis (48%) followed by ATN(18%) followed by thrombotic microangiopathy (12%) followed by malignant lymphoma(6%) followed by acute pyelonephritis (4%) followed by renal cortical necrosis (2%)and interstitial hemorrhage (2%). In adults, the cause of ARF in our study were ATN (38%) followed by acute glomerulonephritis (23%) followed by thrombotic microangiopathy (15%) and acute pyelonephritis (15%). The renal biopsy confirmed the clinical diagnosis in 58% of the children cases, and 23% of the adults cases. The result of the biopsy had altered clinical diagnosis in 12% of children cases and 8% in adults cases. However in cases with unknown clinical diagnosis the renal biopsy clarify the diagnosis in 30% in children cases and 69% in adult cases. |