الفهرس 
Introduction
Pathophysiology of painOnly 14 pages are availabe for public view
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Abstract
Aim of work: This study was designed to compare homodynamic variables and postoperative analgesia following propacetamol and different doses PCA morphine after major abdominal surgery. Patients: Thirty patients were included in this study (ASA I & II) of either sexes with age ranging from 20 to 60 years. The candidate patients were scheduled for different elective major abdominal surgery. The studied patients were divided into three groups Methods: Group I Postoperative analgesia started ten minutes before skin closure with proparacetamol 2g i.v drip infusion (dextrose 5%, 100 ml in 15 min) then after 12hours for all groups. Then PCA started as following setting (bolus dose 0.5 mg morphine lockout interval 8 minutes without background infusion with maximum four hours limit 30 mg) for 48 hr Group II PCA by following setting (bolus dose 0.1 mg morphine lockout interval 8 minutes without background infusion with maximum four hours limit 30 mg) for 48 hr Group III PCA by following setting (bolus dose 1.5 mg morphine lockout interval 8 minutes without background infusion with maximum four hours limit 30 mg) for 48 hr Results: The quality of analgesia in group III was better than other groups, which in low dose morphine (0.5mg) no recorded side effects in group II (1mg) 10% of patient had nausea and vomiting and in group III (1.5 mg) 20% of patients had nausea and vomiting so with increasing dose of morphine more complications.Conclusion: PCA variable doses morphine combined with paracetamol give satisfactory analgesia and group I low dose morphine without side effects recorded.